Carboxymethyl chitosan CAS 83512-85-0

Chemical Properties:

1. Carboxymethyl chitosan is a biocompatible and biodegradable material that is suitable for various applications such as sustained or controlled release drug delivery, pH-responsive drug delivery, gene delivery as permeation enhancer, Carboxymethyl chitosan is a coating material on nanocarriers.

2. Carboxymethyl chitosan is a water-soluble chitosan derivative and an amphoteric polyelectrolyte. It is formed by introducing a hydrophilic group -CH2COOH into the chitosan polymer chain. After base modification, the water-soluble Chemicalbook property is improved, especially the solubility in neutral and alkaline solutions is significantly enhanced, making it have the characteristics of film formation, thickening, moisturizing, chelating, etc., so it is used in agriculture, It has a wide range of applications in medicine, health products, cosmetics, preservation, and environmental protection.

Application:

1. Carboxymethyl chitosan (CMC) is a carboxymethylated derivative of chitosan. It has strong polarity and is easily soluble in water. It has been widely used in the fields of pharmacy and biomedical material development. Since the content of carboxymethyl chitosan in the drug will directly affect its antibacterial and anti-infective clinical effects, it is particularly important to accurately quantify carboxymethyl chitosan. Preparation: Add sodium hydroxide to the isopropanol solution in the reaction flask, the concentration of sodium hydroxide is 40%.

2. Add chitosan Chemicalbook with a degree of deacetylation of 15%-45% into the reaction flask, and the mass ratio of chitosan to sodium hydroxide after adding is 1:4.8. The pre-dissolved isoacetone solution of chloroacetic acid was slowly added dropwise to the reaction flask under stirring, and the reaction was continued to stir for 3 hours after the addition. The mass ratio of chitosan to chloroacetic acid is 5:1. After the reaction is completed, add concentrated hydrochloric acid to the reacted material, adjust the pH of the material to 6-7, filter with suction, wash the filter cake with absolute ethanol 3 times, and dry the washed filter cake below 50°C to obtain a carboxymethyl shell Crude glycan.