Chlorhexidine Diacetate CAS 56-95-1

What is Chlorhexidine Diacetate?

The chemical name of chlorhexidine acetate is 1-6 dihexane diacetate. Also known as chlorhexidine acetate, chlorhexidine acetate, hexamethylene biguanide, and chlorhexidine biguanide, as biguanide compounds, it has very strong antibacterial and bactericidal abilities. It has stronger antibacterial effect on Gram-positive bacteria and Gram-negative bacteria than disinfectants such as chlormethionine. The pharmacological mechanism of chlorhexidine acetate is that it can be adsorbed on the permeability barrier of bacterial cell membranes, allowing cell contents to leak out. Low concentrations can inhibit bacteria, and high concentrations can kill bacteria. Therefore, chlorhexidine acetate is a very ideal broad-spectrum bacteriostatic agent and bactericide. Secondly, due to its rapid and durable curative effect, stable properties, low toxicity, and long-term use, it is not easy to develop drug resistance. Chlorhexidine acetate is mainly used as a surface disinfection preservative in China. Its bactericidal effect is higher than that of similar products commonly seen on the market, such as benzalkonium bromide, domiphene, dextromethamine, qingdujing and other quaternary ammonium salt cationic surfactants. The effect is good and the penetration is extremely strong.

In addition to being used externally as a disinfectant and antiseptic, it also has significant effects in the prevention and treatment of other diseases. Chlorhexidine acetate can be used as an alcohol substitute, and the effect is far better than alcohol. It can also be used to disinfect drinking water, prevent intestinal infectious diseases, treat bacterial dysentery, fungal and bacterial infections of the skin, throat, eyes, mouth, ears, nose, vagina, anus, etc., as well as burns, frostbite, and underarm odor. In terms of food, it can be used as a preservative. It has the advantages of low dosage, low cost, long storage time, no impact on taste, and no toxic or side effects. It is superior to similar products currently in use. In addition, chlorhexidine acetate can also be used as a disinfectant in daily life, such as disinfecting rooms, bathrooms, tableware, furniture, clothing, etc.

Chlorhexidine Diacetate Uses

Chlorhexidine acetate is a commonly used disinfectant. Compared with other disinfectants, it has certain advantages because it is a chlorine-containing disinfectant that can kill some viruses, which is an effect that other chlorine-free disinfectants do not have.

In the operating room, chlorhexidine acetate is often used to disinfect the postoperative environment because it can not only kill common bacteria, but also inhibit and kill viruses. After washing hands, using chlorhexidine acetate can have a certain inhibitory effect on bacteria and viruses on the hands, so chlorhexidine acetate is widely used in the operating room.

In addition to sterilization and elimination of viruses, it can also be used to clean mops used in operating rooms, which can kill bacteria and viruses on them. Therefore, chlorhexidine acetate is widely used in surgery, mainly because chlorine-containing disinfectants have better sterilization and virus killing effects.

Chlorhexidine acetate is highly sensitive to some Staphylococci, Streptococcus mutans, Streptococcus salivarius, Candida albicans, Escherichia coli, and anaerobic propionibacterium, moderately sensitive to Streptococcus sanguinis, and relatively low in sensitivity to bacteria such as Proteus, Pseudomonas, and Klebsiella.

It is generally used for disinfection of skin and mucous membranes, flushing of wound infections, vaginal infections, and uterine erosions. It can be used for oral mucosa, stomatitis, and gingivitis. For external use, it can be used to treat vaginitis, cervical erosion, and increased leucorrhea caused by pathogens such as gonorrhea and Trichomonas. It can also be used for cleaning and health care before gynecological examinations, before and after abortions, before and after sexual intercourse, and after childbirth.